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Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine doi: 10.1007/s11684-023-1005-y

Abstract: A variation within TRMT2B (c.1356G>T; p.K452N) was identified to be associated with ALS in a familylevel of ROS were observed functionally in patient-originated lymphoblastoid cell lines and TRMT2BFurther, TRMT2B variations overexpression cells also displayed decreased ND1.In conclusion, a novel JALS-associated gene called TRMT2B was identified, thus broadening the

Keywords： TRMT2B     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygen    

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Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 101-105 doi: 10.1007/s11684-010-0017-6

Abstract: Phospholipase A2 (PLA2) is a crucial element for normal neuro-physiological function.(cPLA2) family genes and schizophrenia among Han Chinese in the northern part of China.The genotypic frequency of cPLA2 gene did not deviate from Hardy-Weinberg equilibrium either in caseThe conditioning on allele (COA) and conditioning on gene (COG) tests showed disease associations withOur data suggest that many loci in the cPLA2 family genes may be associated with schizophrenia.

Keywords： schizophrenia     cytosolic phospholipase A2     ligase detection reaction     polymorphism    

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Adenovirus-mediated antisense ERK2 gene therapy ameliorates chronic allograft nephropathy in a rat model

Zhao DING, Zhishui CHEN, Xilin CHEN, Ming CAI, Hui GUO, Nianqiao GONG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 204-210 doi: 10.1007/s11684-009-0039-0

Abstract: To investigate the effect and underlying mechanism of adenovirus-mediated antisense ERK2 (Adanti-ERK2) gene therapy upon chronic allograft nephropathy (CAN) of rats, male Lewis (LEW, RT11) rats receivedThe recipients were divided into three groups: (1) empty control group; (2) vector control group; (3)gene therapy group.Adanti-ERK2 gene therapy protects the renal allograft and attenuates graft fibrosis, which may be correlated

Keywords： anti-ERK2     renal transplantation     epithelial mesenchymal transition     chronic allograft nephropathy    

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a novel K+ transporter gene in cotton

Yiru WANG, Juan XU, Mingcai ZHANG, Xiaoli TIAN, Zhaohu LI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 226-235 doi: 10.15302/J-FASE-2017170

Abstract: This study, identified a K transporter gene, expressed in the roots of cotton ( ) cv.Consistently, b-glucuronidase (GUS) expression driven by the GhKT2 promoter could be detected in rootsTaken together, this evidence indicates that GhKT2 may participate in K acquisition from low or high

Keywords： cotton     GhKT2     potassium     transporter     uptake    

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Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 90-95 doi: 10.1007/s11684-010-0021-x

Abstract: This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene

Keywords： cyclooxygenase-2 gene     single nucleotide polymorphisms     susceptibility     primary hepatocellular carcinoma    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functionIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticsresponsible for disseminated superficial actinic porokeratosis (DSAP) was identified at Chromosome 12q23. 2- 24. 1; and at the same year a novel protein trafficking gene was also cloned from gene function study

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Cotransfecting norepinephrine transporter and vesicular monoamine transporter 2 genes for increased retention

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 120-128 doi: 10.1007/s11684-017-0501-3

Abstract: prolong the retention of 131I-MIBG in target cells, we infected hepatocarcinoma (HepG2)cells with Lentivirus-encoding human NET and vesicular monoamine transporter 2 (VMAT2) genes to obtain NET-expressing, NET-VMAT2-coexpressing, andof 131I-MIBG-containing medium, 25.4% efflux was observed in NET-VMAT22 cells with NET and VMAT2resulted in increased 

Keywords： norepinephrine transporter     vesicular monoamine transporter 2     -MIBG     gene therapy     lentivirus    

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RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: In this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and tested

Keywords： pseudorabies virus     RR1 and RR2     ribonucleotide reductase     vaccine candidate    

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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer.This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinesepatients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative(HER2 ) breast cancer.Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with

Keywords： early breast cancer     21-gene assay     recurrence score     prognosis    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract: We propose that the resistance gene flow in nature is “from the natural environments” andand animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 211-217 doi: 10.15302/J-FASE-2019303

Abstract: functions regarding economic traits, and new materials for livestock breeding have been obtained through geneEvaluation is the most important component of the regulation of gene-edited livestock and is a crucialguarantee of public safety before the marketing of gene-edited animal products.Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production

Keywords： evaluation     gene editing     livestock     performance     safety    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 141-147 doi: 10.1007/s11684-009-0041-6

Abstract: To explore the possibility of Rab9-related gene therapy for neurodegenerative diseases, we packed LentivirusAfter 72 hours, the expression of GFP could be detected in BV-2 cells.Western blotting revealed that the Rab9 gene expression in BALB/c mice brain was up-regulated significantlyLentivirus encoding Rab9 can increase the expression of Rab9 gene effectively, which might offer a novel

Keywords： Rab9     lentivirus     gene therapy     gene transfer    

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Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation-2:1 is downregulated in congenital heart disease and regulates cell proliferation by targeting HAND2

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 91-100 doi: 10.1007/s11684-020-0778-5

Abstract: We used Gene Expression Omnibus data mining, bioinformatics analysis, and analysis of clinical tissueKnockdown of lncRNA SAP30-2:1 inhibited the proliferation of human embryonic kidney and AC16 cells anddecreased the expression of heart and neural crest derivatives expressed 2 (HAND2).Moreover, lncRNA SAP30-2:1 was associated with HAND2 by RNA immunoprecipitation.cell proliferation via targeting HAND2 and may thus represent a novel therapeutic target for CHD.

Keywords： congenital heart disease     Gene Expression Omnibus     lncRNA SAP30-2:1     cell proliferation     RNA immunoprecipitation     HAND2    

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Title Author Date Type Operation

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Journal Article

Adenovirus-mediated antisense ERK2 gene therapy ameliorates chronic allograft nephropathy in a rat model

Zhao DING, Zhishui CHEN, Xilin CHEN, Ming CAI, Hui GUO, Nianqiao GONG

Journal Article

a novel K+ transporter gene in cotton

Yiru WANG, Juan XU, Mingcai ZHANG, Xiaoli TIAN, Zhaohu LI

Journal Article

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Cotransfecting norepinephrine transporter and vesicular monoamine transporter 2 genes for increased retention

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Journal Article

RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Journal Article

Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation-2:1 is downregulated in congenital heart disease and regulates cell proliferation by targeting HAND2

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

Journal Article